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In many cases, metal binding provides a major driving force for a polypeptide chain to fold.
The minimum number of H-bonds required for the ligand binding provides a reasonable explanation to the effectiveness of nilotinib against most imatinib resistant mutants.
Clustering of integrins upon matrix binding provides a bidirectional crosstalk between the inside and outside signaling.
For synaptotagmin I, it was suggested that direct tubulin binding provides a mechanism for retaining synaptic vesicles on microtubules as a readily releasable pool.
The accurate prediction of peptide-MHC binding provides a useful approach to candidate T cell epitope selection since it allows the number of experiments needed for their identification to be minimised.
Thus, DNA binding provides an avenue both to acquire a local and high concentration enough to facilitate the formation of aggregation-prone protein conformations and to enable the protein aggregation.
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However, the opinion, which is not legally binding, provided commission members with two options for monetary caps on contributions.
In fact, all the rare gases (helium, neon, argon, krypton, and xenon) are molecular crystals with the binding provided by van der Waals forces.
Often, crystal structure determination is regarded as ultimate proof for ligand binding providing detailed insight into the specific binding mode of the ligand to the protein.
The most distinctive structural features are located in regions implicated in receptor and antibody binding, providing insights into the cell entry mechanisms and antigenic nature of AAVs.
The present study focuses on analyzing the conformational changes in various antibodies upon binding, providing quantitative observations to be exploited for antibody-related modeling.
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