However, functions of GAGA-motif binding proteins are more diverse and can also be linked to epigenetic regulation of homeotic genes e.g. by recruiting silencing factors to specific sites, as well as influencing the promoter-proximal pausing of RNA Polymerase II (Pol II) [5], [9], [10], [11].
It is thus likely that its telomere binding proteins are more closely related to those of vertebrate species compared to the current yeast models.
The present studies have shown an increase in the mRNA of enzymes involved in the cholesterol biosynthesis pathway, implying that the sterol regulatory element binding proteins are more active in the liver and small intestine in lactating vs nonlactating rats.
As clearly shown in Table 1 HCV-binding proteins were more enriched in top-DCGs than in top-DEGs: except for one case, all top-DCG sets were significantly enriched with HCV-binding proteins, whereas none of top-DEG sets were enriched with HCV-binding proteins.
In contrast, the chlorophyll binding protein was more abundant in Krishna mature leaf samples.
In addition, it may suggest that filament-binding proteins are more likely to contact multiple subunits within a filament strand than between filament strands.
It remains to be determined whether alternative proteins substitute for Hdac6 in differentiated cells to recruit Tip60-p400 to different promoters, or if alternative mechanisms of recruitment (e.g., binding to histone modifications or interaction with sequence-specific DNA-binding proteins) are more important upon differentiation.
The results, visualized in Figure 4B, demonstrate that sites binding exactly two proteins were more enriched within 50 kb of breakpoints than sites binding exactly one in the genophilic cancers: Breast-Inaki (p = 2.3⋅10-5), Breast-Stephens (p = 0.0021), Breast-NikZainal (p = 0.22), Ovarian-McBride (p = 0.022) and Colorectal-Bass (p = 0.05).
This may indicate that genes associated with structural, RNA and lipid binding proteins were either more apt to be duplicated, or that these genes once duplicated as a result of the two rounds of large scale duplication observed by Schlueter et al [ 6], were retained whereas the duplicated genes in other classifications were lost or diverged significantly in primary sequence.
