For instance, there are an increasing number of reports that deficiencies or altered functioning of both membrane-associated and cytoplasmic lipid binding proteins are associated with disease states, such as obesity, diabetes and atherosclerosis [ 47, 48].
For that reason, LPA signaling has been linked to cancer, which means that an overexpression of Rho-GTPase binding proteins is associated with lysophosphatidic acid signaling.
Assuming that increased levels of retinoid binding proteins are associated with more effective retinol internalization, the tissues of the MRL/MpJ mouse could display an enhanced sensitivity to retinoid stimulation.
The physiological relevance of mRNP biogenesis control is supported by the fact that altered expression or dysfunction of some RNA binding proteins are associated with various diseases including cancer, as for example that of some 3'-end processing factors and of some proteins involved in alternative splicing [ 3, 4].
Interestingly, high levels of galectin-3 binding protein were associated with high levels of cartilage oligomeric matrix protein, which is a marker of synovial cell activation and joint destruction [ 77].
In a case control cohort study, Rock et al. [ 22] evaluated whether serum concentrations of estradiol, testosterone, and sex hormone binding protein were associated with recurrence free survival in women who were followed for more than 7 years after BC diagnosis.
Overexpression of heterogeneous nuclear ribonucleoprotein K (hnRNP K), a DNA/RNA binding protein, is associated with metastasis in nasopharyngeal carcinoma (NPC).
Association analysis revealed that the SNPs in CRHR1 and CRHBP (corticotropin-releasing hormone binding protein) are associated with blood mRNA concentrations in both alcohol-dependent patients and nondependent controls [ 39].
Our study found evidence that two SNPs in vitamin D-binding protein were associated with prostate cancer risk (rs4588-andnd rs7041-T).
Low serum level of vitamin D is an important risk factor for TB, and polymorphisms in both vitamin D receptor (VDR) and vitamin D-binding protein are associated with increased TB susceptibility [40, 41].
