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DAZ family proteins interact with several other RNA binding proteins to regulate translation in diverse organisms [12] [16].
Once in the nucleus, Smads can target a variety of DNA binding proteins to regulate transcriptional responses.
In C. elegans, proteins with homology to splicing factors commonly also function as RNA binding proteins to regulate gene expression posttranscriptionally (Tamburino et al. 2013).
The activated R-Smads form heteromeric complexes with co-Smad (Smad4) and then enter the nucleus, associating with other DNA binding proteins to regulate downstream gene transcription.
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In addition to its critical role in enzyme catalysis, TS functions as an RNA binding protein to regulate the expression of its own mRNA translation and other cellular mRNAs, such as p53, at the translational level.
We postulated that AdpA might frequently interact with other DNA-binding proteins to regulate target genes.
Epigenetic modifications either influence the accessibility of cis-regulatory elements in genomic DNA or recruit chromatin-binding proteins to regulate gene expression.
Here, we define a novel mechanism by which lncRNAs modulate miRNA expression at the transcriptional level by binding to RNA-binding proteins to regulate human spermatogenesis.
In contrast, lncRNA has poor sequence conservation, and through its primary, secondary and tertiary structures, interacts with RBPs (RNA-binding proteins) to regulate gene expression at transcriptional or post-transcriptional levels [ 14, 17].
This may not be surprising in light of seminal studies showing that CT and pertussis toxin work through different guanine triphosphate (GTP -binding proteins to reGTP -bindingcellular cAMproteins [ 42, 43].
SEI1 is a CKD4-binding protein to regulate CDK4 activity [ 36] and was up-regulated following 5-FU exposure.
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