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For example, MMPs cleave growth factor binding proteins that sequester and prevent growth factors from binding their receptors.
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Dps proteins are DNA- binding proteins that protect bacteria from oxidative stress by sequestering iron and oxidants and storing them as benign ferric oxide minerals [66].
Subsequently, the inhibitory proteins that sequester NF-κB in the cytoplasm are phosphorylated, ubiquitinated, and degraded in the proteasome.
At the membrane level, the access to receptor is controlled by soluble proteins that sequester TGF- β ligand (i.e. decorin) [ 10], and by membrane-bound co-receptors that promote binding (i.e. betaglycan) [ 11].
GDP Dissociation Inhibitors (RhoGDIs) are important regulators of the Rho proteins that sequester the GDP – bound Rho proteins in cytoplasm.
Phosphorylation of CRTC3 provides a docking site for 14-3-3 14-3-3 14-3-3 sequester CRTC3 in the cytosol [ 19].
Thymosin β-10 (TB10) is a small G-actin binding protein that induces depolymerization of intracellular F-actin pools by sequestering actin monomers.
MT's are an ubiquitous class of metal-binding proteins that function in the homeostasis of essential metals, as well as serving a detoxification role by sequestering toxic metals.
Metallothioneins are ubiquitous metal-binding proteins that function in the homeostasis of essential metals, such as zinc and copper, as well in detoxification mechanisms by sequestering toxic metals such as cadmium, lead, and mercury [ 73, 74].
Gluten contains lectins, sugar-binding proteins that studies show can cling to insulin receptors and create insulin resistance.
Ferritin is a ubiquitous Fe storage protein that sequesters as many as 4,000 Fe atoms in a complex (Theil 2003).
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