Perhaps they alter the binding sites of transcription factors and DNA-binding proteins that protect the DNA molecule from methylation.
9 In addition to expression in the tissue of origin, miRs can be isolated from circulating blood, where they remain extremely stable due to their transport in association with microvesicles and exosomes, or in tight association with RNA-binding proteins that protect them from ribonuclease degradation.
For instance, we detected Dps, a DNA-binding protein that protects DNA during stress; Daigle et al. also identified dps using selective capture of transcribed sequence (SCOTS) technology to analyze S. Typhi genes expressed within macrophages [26].
Because metallothionein (MT) is a metal-binding protein that protects against metal intoxication, it could be a biomarker for individual sensitivity to metal toxicity.
It is mediated by a 218-aa protein, Qnr (lately termed QnrA), which belongs to the pentapeptide repeat family of proteins that protects DNA from quinolone binding to topoisomerases (4, 5 ).
Telomeres, the linear ends of eukaryotic chromosomes, consist of specialized tandem (TTAGGG n DNA repeats and associated telomeric binding proteins that serve to protect the ends of chromosomes from recombination, end-to-end fusion and degradation, thereby maintaining chromosomal integrity (Blackburn 1991).
Gluten contains lectins, sugar-binding proteins that studies show can cling to insulin receptors and create insulin resistance.
Footprint count measurements for each extension are highly correlated between libraries made using these two sample preparation methods, indicating that these footprints are either protected by 80S ribosomes, or by another RNA binding protein that co-sediments with 80S ribosomes.
The mechanisms in microorganisms that respond to high temperatures have been shown to be multidimensional, involving DNA-binding proteins, specific topoisomerases, repair mechanisms that protect against DNA damage (Forterre 2002; Brochier-Armanet and Forterre 2007), more rigid membranes (Koga 2012), etc.
The scientific record can act as a legally binding record that protects intellectual property (IP) [39].
