The abnormally expressed proteins could be integral factors responsible for oxidative stress reaction, or antioxidants or different binding proteins that may bind oxidants and antioxidants such as superoxide dismutase (SOD), paraoxonase (PON), hemopexin, apolipoproteins, and heat shock proteins [ 8– 13].
This may be due to the very low binding affinity of D3 to ERα, as shown by the high dose required for both reporter gene activity and uterine bioassay, or it may result from use of the crude cytosolic preparation containing binding proteins that may bind nonspecifically to D3, preventing interaction with ERα.
In addition, the assay was performed in isolation of other polypyrimidine binding proteins that may normally compete with PTB1 for the binding sites within TrkB and prevent the binding of PTB1.
This study identified enolase, beta-ARK, translation elongation factor EF-1 alpha/Tu, and cadherin mosquito as binding proteins that may play important roles as host factors during viral infection of mosquito cells.
In search for AQP2 binding proteins that may control its trafficking, a PDZ-domain containing protein SPA-1 (signal-induced proliferation-associated gene-1) was identified (Noda et al. 2004a).
Allam et al. [ 6] in their study on bladder tissue from animals actively colonized by U. parvum demonstrated significant alterations in actin binding proteins that may influence cell signaling cascades regulating cell motility, differentiation, apoptosis, and inflammation.
ZFAM5 was originally identified in mouse as a cellular MPK38 serine/threonine kinase binding protein that may be involved in early T cell activation and embryonic development [ 15].
The Middle gene product AS 2031 shares sequence similarity with the Drosophila gene product Bicaudal C, a RNA binding protein that may play a role in translational silencing of maternal mRNAs in addition to its role in eggshell patterning [ 70].
Furthermore, fortification of food on a national basis with vitamin D is necessary to overcome such low levels; and determining the association of SNPs markers of inactivating enzymes and/or vitamin D binding protein that may contributed to the low plasma 25(OH D levels among Jordanians are warranted.
Plasma proteins contain growth factors that may aid in rate of recovery as well as virus-binding proteins that may reduce infection pressure in the intestine.
FUS and TDP-43 are structurally related RNA-binding proteins that may have overlapping functions and form complexes with other RNA-binding proteins [ 25].
