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An alpha phage display library/overlay assay strategy was used to identify binding proteins that interact with active PKC isoforms.
The currently available methods to purify SUMOs harbor the risks of copurifying matrix-associated contaminants and SUMO binding proteins that interact noncovalently with SUMOylated proteins via SIMs.
Among the various DNA binding proteins that interact with this sequence, only NF-Y has been shown to absolutely require all five nucleotides (Mantovani, 1998).
The final translational mechanism is centered around a number of recent observations suggesting that LIP translation may be controlled by specific RNA binding proteins that interact with the 5' region of C/EBPβ mRNA [ 49].
First, an amino acid signature peptide that uniquely recognizes a specific RNA modification or combination of modifications becomes a tool in the study of RNA binding proteins that interact with RNA in a modification-dependent manner.
They play an active part in gene regulation by binding proteins that interact to organize chromatin into loops thought to define autonomous chromatin domains (reviewed in [ 1, 2]), thereby modulating the activities of enhancers and silencers in specific tissues and/or developmental stages.
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ADAR deaminases are RNA-binding proteins that interact directly with their substrates (Klaue et al., 2003).
TFs are sequence specific DNA-binding proteins that interact with the promoter regions of target genes and modulate gene expression.
Annexins including ANXA2 and ANXA5 are family of Ca2+-regulated membrane-binding proteins that interact with the cellular membrane.
Chemokines are small heparin-binding proteins that interact with their receptors, regulating many pathophysiological responses in hematological malignancy and inflammatory diseases [ 21, 22].
Ccr4-Not is recruited to target mRNAs by sequence-specific RNA-binding proteins that interact with different subunits of the complex [ 8– 11].
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