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Streptomyces telomeres bind a family of conserved terminal binding proteins that have no orthologs in the K. radiotolerans genome.
The X-ray crystal structures of several important vitamin B12 binding proteins that have been solved in recent years have enhanced our current understanding in the vitamin B12 field.
Human Muscleblind-like 1, 2 and 3 (MBNL1-3) are RNA binding proteins that have been involved in numerous diseases.
Tropomyosins are actin binding proteins that have been shown to play roles in the establishment of neuronal polarity [61], but a role for these proteins in the developing retina has not been explored.
These observations suggest that EBNA1 is a member of a family of viral origin binding proteins that have no apparent orthologue in the human genome, and therefore may represent attractive targets for inhibitors of viral latent replication and persistence.
Nearly a dozen DNA binding proteins that have insulator/architectural activity have been discovered.
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Subsequently, we identified the individual proteins of porcine MFGM (i.e. lactadherin, butyrophilin, adipophilin, acyl-CoA synthetase and fatty acid binding protein) that have binding affinity for F4ac fimbriae of ETEC [ 4, 5] and demonstrated that porcine lactadherin interfered with attachment of F4+ ETEC to intestinal villi in vitro [ 4].
Since ssDNA is very similar in structure to ssRNA we tested whether ssRNA-binding proteins that have been discovered to have modular recognition properties could be adapted for programmable ssDNA binding.
These cofactors are dsRNA-binding proteins that have differential preferences for siRNA and miRNA.
S100 proteins (also called calgranulins) are a group of calcium-binding proteins that have been proposed as potential alarmins, particularly those expressed in phagocytes (S100A8, -A9, and -A12) through their interaction with RAGE and TLR4 [35] 35].
Plastins are actin-binding proteins that have three cell-type specific isoforms: T-plastin, L-plastin and I-plastin.
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