Some cells express lectins, which are carbohydrate-binding proteins that exhibit high specificity for sugar molecules.
First, existing tools tend to limit analyses to transcription start sites, but ENCODE data also include chromatin remodelers, DNA repair proteins and other classes of DNA-binding proteins that exhibit more promiscuous binding patterns.
We report a new RNA-binding protein that exhibits cytoplasmic inclusions in spinal motor neurons and dentate granule cells in ALS and FTLD-TDP patients.
To demonstrate FIMO's functionality, we searched the human genome with a motif for CTCF, a highly conserved zinc finger DNA-binding protein that exhibits diverse regulatory functions and that plays a major role in the global organization of the chromatin architecture of the human genome (Phillips and Corces, 2009).
Annexins are a family of structurally related proteins that exhibit Ca2+-dependent binding to anionic phospholipids and have been associated with several distinct biological functions [1].
Bax, a proapoptotic member of the Bcl-2 family of proteins, was first discovered in a screen of proteins that exhibited binding interactions with Bcl-2 (Oltvai et al, 1993).
High-mobility group box 1 (HMGB1) is a DNA-binding protein that also exhibits proinflammatory cytokine-like activity.
Our results showed that the BIAcore approach readily identified naturally occurring sequence polymorphisms in the carboxyl terminus of MV N protein that exhibited reduced binding to HSP72, a result correlated to loss of activity control in functional assays.
The M proteins of GAS are also multifunctional proteins, which as a group, exhibits binding for numerous host proteins that include plasminogen, fibrinogen, immunoglobulins and complement regulatory proteins, as recently reviewed by Smeesters et al [35].
