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S-oligos act as heparin mimetics and they bind to heparin binding proteins such as bFGF (Benimetskaya et al, 1995).
Once RA is synthesized, it binds to cytosolic RA binding proteins (such as CRABP).
Most DNA binding proteins, such as transcription factors, bind to cis-acting DNA element with specific sequence features usually described by a position weight matrix (PWM).
Furthermore, other SH3 binding proteins, such as Abi 1 and 2, are phosphorylated by c-Abl7,8 and are therefore unlikely to inhibit it.
Indeed, it has been shown that RNA binding proteins, such as MBNL1, are sequestered away from their normal RNA targets by interaction with the expanded repeats32.
Intracellular actin filament activity is modulated by a number of actin binding proteins such as profillin, actin depolymerizing factor (ADF /cofilin, myosin, fibrin and villin.
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Second, ssDNA is sequestered in cells by non-specific ssDNA-binding proteins, such as replication protein A (RPA 2, limiting the access of RNA-binding proteins.
Other newly described mammalian cAMP-binding proteins such as Popdc and CRIS may someday be exploited in sensor design.
Thermostable cross-β structures are characteristic of pathological amyloid fibrils, but these structures cannot explain the reversible nature of fibrils formed by RNA-binding proteins such as fused in sarcoma (FUS), involved in RNA granule assembly.
One plausible mechanism for the nucleation and seeding of TDP-43 pathology is the assembly of stress granules (SGs) that could trap RNA-binding proteins such as TDP-43 into the cytoplasm28,29,30,31,32,33,34,35.
Importantly, other actin-binding proteins such as fimbrin and espin show high specificity between these two bundle types within the same reaction.
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