Overall, as we do not observe a significant increase in Pf parasitemia in the Duffy A+/A− individuals tested, our observations suggest that efforts to develop Pv-specific vaccines should be pursued, and emphasize that strategies to target the Pv Duffy binding protein should be strongly considered.
As calcineurin has such a high affinity for CaM, the effect of CaM-peptide on the interactions of CaM and other CaM-binding proteins should be examined.
In order to identify the entire complement of proteins driving the transformation machinery, the complete set of neisserial DNA-binding proteins should be defined (Lång et al., 2009) (Fig. 3).
That cap optimizes miRNA silencing strongly suggests that a cap-binding protein should be involved in miRNA repression (Kiriakidou et al., 2007).
In theory, when using pH values closer to the isoelectric point, the binding of other proteins should be less.
Because AnxA2 heterotetramers are Ca2+-dependent phospholipid-binding proteins, the heterotetramer proteins should be stripped from the cell surface by Versene.
Furthermore, the PA-interacting/binding proteins should be studied in more detail to illustrate the downstream mechanisms.
If ARFGAP1 acted upstream of any of the small GTP-binding proteins tested, serum activation of that protein should be diminished in GFP-GAP273 (3.2) cells.
This should include actin and other cytoskeletal networks, cadherin, and actin-binding proteins and should be correlated with real-time observations of junctional dynamics.
All these results suggest that dose should not be individualised according to baseline AAG level, but that protein binding phenomena should be considered when the relationship between total plasma docetaxel concentrations and PD is evaluated.
