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Mammalian IGFBP-6 has a 10 100 fold higher affinity for IGF-II than IGF-I [65], so we suggest that downregulation of IGFBP-6 may increase the availability of IGF-II to other binding proteins required for differentiation.
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Cbf1p is a sequence specific DNA binding protein required for MET16 chromatin remodelling and transcription.
CBP2 is an RNA tertiary structure binding protein required for efficient splicing of a yeast mitochondrial group I intron.
PGPS/D3, a calcium binding protein required for pollen germination in Petunia, is similar to the myristoylated mammalian protein neuromodulin [ 34].
An alternative explanation is that the PTEN-tail-only domain inhibits the binding of another PDZ binding protein, required for EMT, although we favor the former hypothesis.
B0280.5 mRNA is expressed specifically in the adult hermaphrodite germ line and is a target of GLD-1, an RNA binding protein required for oocyte meiotic cell cycle progression [ 48].
Examples of myristoylated plant proteins include a Rab GTPase required for endosomal sterol transport [ 9, 10], a calcium binding protein required for salt tolerance [ 11], and calcium-dependent protein kinases from Arabidopsis thaliana, Oryza sativa, Lycopersicon esculentum, Cucurbita pepo, and Solanum tuberosum [ 12- 16].
The aECM components Serpentine (Serp) and Vermiform (Verm) are predicted chitin-binding proteins required for limiting tracheal tube elongation [15] [17].
Throughout early development, PGCs express the germ cell specific gene Dazl (Deleted in AZoospermia-Like), a member of the DAZ gene family, which encodes RNA-binding proteins required for germ cell development in diverse organisms [11].
Copper (Cu) chaperones constitute a family of small Cu+-binding proteins required for Cu homeostasis in eukaryotes [ 29].
In all species examined, the germ plasm contains microscopically visible P granule-like structures that are enriched for conserved mRNAs and RNA-binding proteins required for germ cell development (e.g., nanos RNA and VASA-related helicases) (Voronina et al., 2011).
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