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Additional dengue 3' SL binding proteins may have been present in the affinity column eluates that were not readily distinguishable in the stain patterns or northwestern blots.
A number of cellular and diffusion barriers (e.g., size and charge of hASM, enzymatic inactivation, and sequestration of the enzyme by binding proteins) may have been responsible for limiting the penetration and diffusion of hASM into surrounding CNS parenchyma following ICV infusion.
Calcium binding proteins may have a significant impact on signaling processes and regulate second messenger transmission [ 63].
A recent study identified a small peptide that can interfere with Nck binding to Pak1, which can interfere with angiogenesis [ 48], suggesting that small molecule interference of PAK interaction with its binding proteins may have some therapeutic value.
Intriguingly, HLB disease symptom was initially thought to be related to zinc deficiency and the zinc transport system is required for virulence in other organisms [ 1, 2], and therefore the PP2 subnetwork analysis indicates that zinc transporters or zinc binding proteins may have a potentially important role for citrus to respond to the HLB bacterial infection.
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LC-MS/MS analysis of the captured proteins showed that serum amyloid A (SAA), apolipoprotein E (ApoE), and lipopolysaccharide (LPS) binding protein may have potential to act as prognostic biomarkers.
During this process, 14-3-3 τ, a phospho-serine-binding protein, may have an important role.
In addition, hydrophobic proteins may have fewer available binding domains because a significant proportion of the protein sequence is membrane-bound.
One of these studies identified potential mA-specific binding proteins, which may have functional significance.
However, the complex situation, with protein bound circulating IGF-I and locally produced IGF-I, makes it difficult to demonstrate defined roles for the various IGF-I compartments, particularly when binding proteins themselves may have independent regulatory functions across muscle membranes [ 11, 12].
Clearance of cytokine binding proteins may be important in the resolution of inflammation.
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