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In E. coli, only limited sets of growth conditions have been evaluated and IciA and several other replication origin binding proteins may act as a replication inhibitor during nutrient starvation or during sudden changes in growth rate [15].
The uncharacterised AP2 binding proteins may act to control CBF independent signalling pathways and represent new targets for manipulating the plant's response to low temperature stress.
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It has been suggested that immune complexes containing these autoantibodies directed against RNA-binding proteins may act as endogenous IFN-α/β-inducing factors [ 23].
Further study revealed that plant LIM domain proteins may act as transcriptional activators of lignin biosynthesis, activating the expression of PAL, 4CL, and CAD and/or function as actin binding and bundling proteins [ 26].
The overexpressed or misfolded protein may act as a chaperone substrate and compete with HSF1 for binding resulting in nonspecific activation of the heat shock response [40].
MT, as a zinc binding protein, may also act as an anti-apoptotic factor.
Other β-tail-binding proteins may also act as integrin inhibitors, but their mechanisms of action require further study.
Clearance of cytokine binding proteins may be important in the resolution of inflammation.
Insulin-like growth factor binding protein 3 may act as a direct apoptotic response to hypoxia, and this implies that there are major selective mechanisms in vivo to overcome this pathway and suggests that antagonising the IGF1 receptor could have high selectivity in cancer, with endogenous IGFBP-3 synergising with such inhibition.
Since conditioned medium from these cartilages contains both IGF-I-like peptides and IGF-binding proteins such as BP-25, we suggest that the IGF-binding proteins present may act to down-regulate the growth-promoting effects of the local IGF peptides.
Binding of the T allele to FOXA2 may facilitate an open chromatin structure surrounding intron 8/9, facilitating further access of DNA-binding proteins that may act as a complex transcriptional silencer.
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