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The expression of these genes, together with that of JH esterase and JH binding proteins, is consistent with previous studies implicating tight control of JH during embryogenesis [ 63].
In addition, the concurrent up- and down-regulation of genes coding for calcium binding proteins is consistent with an elaborate role of calcium in plant-aphid interaction, since its concentration is at the core of the molecular sabotage that aphids carry out to avoid sieve-plate occlusion [ 57].
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Our findings on the phylogenetic distribution of important DG-binding-proteins are consistent with the model that the DG-binding proteins of the DGC arose within metazoans, with the cytoplasmic dystrophin being of earliest origin (Fig. 7).
The ability of urate to attenuate DNA binding by mutant proteins is consistent with the observed increase in thermal stability on ligand binding.
Our computational analysis and experiments indicate that binding of VA to proteins is consistent with the hydrophobic effect and the Meyer-Overton rule.
23 We next tested whether the pattern of Bmf binding to antiapoptotic proteins was consistent with a potential role as the agent displacing Bim in parental MCF-7 cells.
Although the proteins were designed for a 5-coordinate myoglobin-like heme binding site, the resulting proteins were consistent with 6-coordinate bis-His-ligated heme.
In the bacterial TSPO of MF37, the high degree of conservation in the region considered to be the ligand-binding domain of the protein is consistent with our observation that PK 11195, a high-affinity ligand of mitochondrial TSPO, was also recognized by this protein with nanomolar affinity.
The observed slow exchange of bound and free protein is consistent with submicromolar binding.
This suggests that Mcm1 tends to collaborate with some non-specific binding proteins, which is consistent with the fact that Mcm1 is a cofactor of multiple TFs (Dolan et al., 1989; Jarvis et al., 1989; Keleher et al., 1989; Mead et al. 2002).
In addition, activated RNA expression of NF-kappa-B inhibitor alpha (NFκBIA; a.k.a I-kappa-B-alpha, IKBα) and toll interacting protein (TOLLIP), both inhibitors of inflammation, along with downregulated expression of the immunoregulatory transcription factor GATA binding protein-1 (GATA1) is consistent with the maintenance of intestinal homeostasis.
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