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The multiplicity of cis-acting regulatory elements is striking, as is the fact that very different motifs and binding proteins can function redundantly to promote recombination.
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Our results here reinforce the earlier notion that many RNA-binding proteins can function as RNAi-suppressors [ 5, 19, 20, 48, 49].
Because it seems that many DNA-binding proteins can function like histones in suppressing C->T mutations (Warnecke et al. 2013), it should be cautious to interpret the so-called dual-used codons or "duons" recently proposed in human genes (Xing and He 2015), which are based on the observation of different synonymous codon choices in regions occupied by transcription factors(Stergachis et al. 2013).
Second, some acetylated lysine sites of histone proteins can function as binding sites for transcription factors [ 5- 7].
Both viral Myb (v-Myb) and cellular Myb (c-Myb) are nuclear sequence-specific DNA-binding proteins that can function as transcriptional activators.
Recent molecular work sheds light on the genetic complexity discovered by Lewis and demonstrates that Ubx executes its developmental role by producing a family of closely related DNA-binding proteins that can function as transcription factors.
CTCF is an evolutionarily conserved zinc finger-containing DNA-binding protein that can function both directly in gene regulation as a transcription factor and also indirectly by mediating long-range chromatin interactions.
S100 proteins are small calcium-binding proteins of the EF hand motif which can function as both intra- and extracellular signaling molecules.
FK506 binding protein 5 can also function within an auto-regulatory negative feedback loop to modulate its own expression.
Because the LARGE modification site is missing (Fig. 3C) it is unclear if these DGs can function as laminin-binding proteins.
We also discovered that human plasma kallikrein can function as a saccharide-binding protein.
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