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Given that many protein domains have sequence lengths between 50 and 100 amino acids and ATP binding proteins are present in every major enzyme class, we felt that the random region and target choice were appropriate to identify small protein domains with simple ligand binding activity [6].
Regarding the pattern recognition receptors, a great variety of PGRPs (peptidoglycan recognition receptors) and GNBPs (gram negative binding proteins) are present in this tissue.
Intriguingly, chromatin regulators encompassing histone modifiers and histone modification binding proteins are present in a combinatorial fashion at distinct genomic loci and frequently bring together regulators associated with opposing activities [27].
In the case of yku70Δ cells bearing telomere repeat tracts that are ~200 bp shorter than those of wild-type cells, we hypothesized that this resection may reduce these tracts to the point where so few telomere binding proteins are present that the telomere becomes dysfunctional and Mec1-HAp is recruited.
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The DNA methylation changes over time in six genes annotated as chromatin/DNA binding proteins are presented in Figure 7C.
An RV xF motif, common to many PP1 binding proteins, is present in the conserved functional core of the PPP1R15 family members and their viral counterparts, and plays an important role in assembly of the active holophosphatase complex (He et al., 1998; Connor et al., 2001; Novoa et al., 2001).
These authors showed that several actin-binding proteins are present in these structures, such as vinculin, paxillin, alpha-actinin, VASP and ERM-proteins.
These results show that several RNA-binding proteins are present in the same complexes as Stau2 isoforms and suggest that only the Stau2/hsc70 interaction involved direct protein-protein interaction.
However, if other DNA-binding proteins are present these may represent non-specific binding of the antibody; conversely, they may merely represent other proteins that normally occur in a complex with the protein of interest on DNA.
In addition to Fur, the H. felis genome encodes orthologues of the Escherichia coli Fec and Feo siderophore-mediated iron uptake systems; multiple copies of frp genes encoding heme- or lactoferrin-binding proteins are present.
Immunoglobulin-binding proteins are present in the tick haemolymph and salivary glands of R. appendiculatus, A. variegatum, I. hexagonus and I. ricinus and it is thought that these proteins are responsible for host immunoglobulin-G excretion via salivation, during the parasite feeding [ 46, 77].
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