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The gland architecture is also relevant: where the peptide is expressed, what the direction of the blood flow is inside the gland, and where the receptors and binding proteins are located.
In normal breast epithelial cells and in most IC-NST, E-cadherin and the associated catenin binding proteins are located at the cell membrane, maintaining cellular cohesion.
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The dynamin Dnm1p, a GTP-binding protein, is located in mitochondria at division sites.
PAI 1 – The ssrA gene (WS105_tm01) from PAI 1 (Fig. 7) is putatively transcribed into a hybrid transfer messenger RNA (tmRNA) [ 42], whereas the gene encoding the cofactor SmpB (WS105_0199), an SsrA-binding protein, is located elsewhere in the genomic sequence.
Given these results, we can investigate whether genes likely to affect element transport or binding to proteins are located under any of these novel peaks.
Interestingly, the putative ice-binding/adhesin proteins are located in a GI (no. 2), which has at its edge a proteorhodopsin gene and its cognate carotenoid monooxygenase and, immediately upstream, ABC-type transporters for complexed iron or cobalamin.
P-glycoprotein (P-gp), which is a member of the ATP-binding cassette (ABC) family of proteins, is located on the plasma membrane and serves as drug efflux pumps.
The spectroscopic experimental results were substantiated by docking results which shows that high and low affinity binding sites of toxin on plasma protein are located within the binding pocket of subdomain IIA and IIIA.
In C. acetobutylicum, CAC1493 and CAC1494, annotated as a Zinc finger DNA-binding domain and a hypothetical protein, are located in a two-gene operon in the chromosome.
Immediately upstream of this region, a gene coding for Cro/C1-type HTH DNA-binding domain-containing protein is located (Dpo_5c00890).
Previously, it has been shown that the fimH adhesin of the type 1 fimbriae, and the papG adhesin of the P fimbriae are the receptor specific binding proteins that are located at the tip of the pilus structure [28].
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