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Moreover, they found that NOVA proteins predominantly bind to these RNA transcripts in the nucleus, which was initially surprising because RNA binding proteins are generally thought to regulate mRNA levels by binding to the untranslated regions of RNA transcripts in the cytoplasm.
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The resulting binding profiles of all five insulator proteins are generally characterized by sharp peaks of local enrichment (Fig. 2a, Fig. S2a).
Consistent with our results at SRG1, we found that at the highly transcribed genes, PMA1, PYK1, and ADH1, the binding of the mutant Spt16 proteins were generally reduced in accordance with the decrease in histone H3 levels across these regions.
Another challenge is that the identification of binding proteins is semi-quantitative and does not generally provide a tight correlation with half-maximal inhibitory values.
We show that dsRNA-binding proteins are prominent autoantigens.
Thus, the flexibility of the myristylated protein is generally increased upon ligand binding and generally decreased upon ligand binding for the nonmyristylated protein.
In fact, due to these same stoichiometric considerations, low concentrations of calcium or apatite binding proteins have been generally associated with nucleation of mineral formation whereas high concentrations are known to usually delay or inhibit this same process [100].
Our findings indicate that protein-protein binding sites are generally protected from alternative splicing-mediated partial removals.
No Vn-binding proteins were detected in the weak Vn-binding strain KR497 (data not shown).
For example, methyl-CpG binding domain proteins (MBDs) are generally thought to be expressed only in neurons and to repress glial genes [78].
Integrin binding protein mimetic peptides are generally more stable than whole proteins, which may be degraded by fibroblasts.
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