Early phase was associated with dramatic up-regulation of structural and metal binding proteins, which were repressed in later phases.
We previously reported that miR-519 represses the production of HuR, an RNA-binding protein which is highly abundant in cancer cells and is low in untransformed cells [ 11, 38].
Consider a protein x1, which represses the production of an RNA species x2.
Drosha and Dicer act as components of larger complexes containing accessory proteins, often double-stranded RNA-binding proteins, which can activate or repress the activity of these complexes.
Presenilin-1 γ-secretase can cleave the cytoplasmic tail of N-cadherin to release a 35 kDa fragment that has the ability to translocate into the nucleus and bind to the transcriptional coactivator CREB binding protein (CBP) and target it for degradation, which represses CBP/CREB-mediated transcription [ 19, 20].
Also, ORF5 encodes a protein similar to LSD1, which represses transcription by demethylating histone H3 at K4, whose methylation is linked to active transcription (Shi et al. 2004).
Here we show that deletion of the eukaryotic initiation factor 4E-binding protein 1 (4E-BP1), a major mTOR downstream effector, which represses eIF4E activity and cap-dependent translation, leads to mechanical, but not thermal pain hypersensitivity.
We identified ZNF703 as a nuclear protein whose expression is stimulated by oestrogen and which represses ER-associated proteins.
This has been described for other zinc finger proteins that are important for T cell proliferation and differentiation, e.g. Ikaros, which represses transcription by binding to the NuRD complex, but may also potentiate gene expression by binding to other proteins [ 25].
Transgelin (SM22α) is a cytoplasmic actin-binding protein, expressed by mesenchymal cells and tumor fibroblasts [ 43] and which represses TGF-β-induced MMP-9 expression [ 44], reduces cell migration, and has tumor suppressor properties [ 45].
