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HuR is an AU-rich element binding protein which has been shown to bind to the 3'-UTR of CAT-1 mRNA to prohibit access to miR-122 [39].
S100A7 is a small calcium binding protein, which has been shown to be differentially expressed in psoriatic skin lesions, as well as in squamous cell tumors of the skin, lung and breast.
Annexin A1 is a Ca2+-dependent membrane binding protein, which has been implicated in membrane trafficking and reorganization.
Although VDR, CYP27B1, and CYP24A1 are the three key genes in this pathway, genes encoding for some other vitamin D metabolizing enzymes, particularly GC encoding for vitamin D binding protein (which has been related to circulating vitamin D levels), may also be related to breast cancer risk and warrant further studies.
We add a brief discussion that addresses the necessity of a secondary cue derived from female cuticles or a lipid binding protein, which has been shown for other pheromone receptors (in the subsection headed "A dual sensory role for Gr68a in courtship initiation").
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By SSH, we identified 8 differentially expressed genes, including classical defence-related genes (PR1, oxidoreductase), and genes affecting photosynthesis (chlorophyll a/b binding protein), which have been characterized elsewhere [ 36, 37].
Each acts through the transcription factor LEF-1/TCF, a member of the family of HMG-box DNA binding proteins, which has binding sites for both Smads and catenin signaling molecules [ 7].
Based on these results, we suggest that TkBCP is a multi-functional DNA-binding protein which has DNA chaperon and antioxidant functions.
When carp (Cyprinus carpio) were exposed to 5 and 30 ppm Cd in the water, the contents of Cd-binding protein, which has low molecular weight, increased in the hepatopancreas, kidney, gills and gastrointestinal tract with the duration of exposure.
Metallothionein (MT) is an intracellular metal-binding protein which has been implicated in various biological roles, including heavy-metal detoxification and zinc and copper homeostasis, and has putative antioxidant properties.
A strict requirement for this pair of exposed hydroxyl groups is consistent with the proposed structure of the ligand complex based on the structure of the closely related asialoglycoprotein receptor and the CRD from mannose-binding protein which has been modified to mimic the specificity for GalNAc (Kolatkar et al. 1998; Feinberg et al. 2000).
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