Sentence examples for binding protein which acts from inspiring English sources

In up to 96% of all classic cases, RS is caused by mutations or deletions in MECP2, a gene encoding for the MECP2 (methyl cytosine phosphate dinucleotide guanine binding) protein which acts as a transcriptional repressor critical for normal neuronal function [4], [5].

Calmodulin is a calcium binding protein which acts as a calcium sensor [ 96] and plays an important role in mediating many cellular processes including muscle contraction [ 97, 98].

LEE1 harbors the LEE encoded regulator (ler) gene, which encodes Ler, a DNA binding protein which acts as a main transcriptional regulator of the LEE region, modulating the expression of other LEE operons [ 13].

Direct activation of the innate immune system via Toll-like receptors, as a result of the release of high mobility group box 1 protein and DNA binding protein, which act as potent cytokine-like mediators in the systemic circulation, leads to an intense inflammatory response within hours of ischaemic renal injury [ 18].

This member of the family of insulin-like growth factor binding proteins, which act as carriers and regulators of insulin-like growth factor, is believed to play an important role in maintaining the equilibrium between synthesis and degradation of tissue matrix molecules.

FOXA2 (previously known as hepatic nuclear factor-3β) is a member of the forkhead class of DNA-binding proteins, which acts as a transcriptional activator of liver-specific genes, and can also interact with chromatin.

Hfq is a bacterial member of the Sm family of RNA-binding proteins, which acts by base-pairing with target mRNAs and functions as a chaperone for non-coding small RNA (sRNA) in E. coli [ 54- 56].

The human Hsp90 co-chaperone FKBP52 belongs to the family of FK506-binding proteins, which act as peptidyl-prolyl isomerases.

Rab8 belongs to a family of small GTP-binding proteins which act as regulators of multiple cellular processes.

Hydroxylation of HIF-1α by PHD2/3 and FIH leads to HIF-1α recognition and binding by VHL proteins, which act as a scaffold for E3 ubiquitin ligase that polyubiquitinates HIF-1α as a signal for proteasomal degradation [ 306, 307].

Targeted DNA methylation, pioneered by Xu and Bestor (16), traditionally employed DNA methyltransferases genetically fused to sequence specific DNA binding proteins, zinc finger proteins, which acted as targeting domains (16− 16−.