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We also found that crabp1, an intracellular retinoic acid binding protein that regulates RA nuclear signaling, was up-regulated from baseline exclusively in the mesenchyme of the limb blastema and was both limb-specific and nerve-dependent (Fig. 5J L).
This mean-independent noise control (MINC) mechanism is investigated in the context of an intracellular binding protein that regulates retinoic acid (RA) signaling during zebrafish hindbrain development.
Previous work identified AKIP1 as a PKA binding protein that regulates nuclear localization of the catalytic subunit of PKA (PKAc) (11).
A CGG trinucleotide expansion in the fmr1 gene suppresses production of the FX mental retardation protein (FMRP), an RNA binding protein that regulates translation through interaction with dendritic ribosomes and has a role in mRNA shuttling [2] [5].
Transcobalamin I (TCN1) is a vitamin B12 binding protein that regulates the absorption, trafficking and secretion.
MBNL is an RNA binding protein that regulates the alternative splicing of the MYOM1 gene [ 233].
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LMO7 mRNA, which was found to be the highest up-regulated feature, is an emerin-binding protein that regulates the transcription of muscle-specific genes [ 11].
Satb2 is a DNA-binding protein that regulates chromatin organization and gene expression.
Septin 6 (SEPT6) is a highly evolutionarily conserved GTP-binding protein that regulates various cell biological behaviors.
Calmodulin (CaM) is a calcium ion-binding protein that regulates a variety of cellular functions through its downstream target proteins.
Cytoplasmic linker protein 170 (CLIP-170) is a microtubule-binding protein that regulates cell motility by modulating microtubule dynamics (Maekawa and Schiebel, 2004).
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