Finally, they report that HuR, an RNA binding protein that promotes endothelial activation by suppressing expression of endothelial nitric oxide synthase (eNOS), is an miR-146 target [ 52].
GLR2.4, also called AUGMIN subunit 8, is a microtubule plus-end binding protein that promotes microtubule reorientation in hypocotyls [ 55, 56].
Finally, we demonstrate that HuR, an RNA binding protein that promotes endothelial activation by suppressing expression of endothelial nitric oxide synthase (eNOS), is a novel miR-146 target.
Hepatoma derived growth factor is a heparin binding protein that promotes the proliferation, differentiation and migration of various cell types, such as vascular smooth muscle cells [ 39].
LATS2 expression is also regulated by TTP (tristetraprolin), an ARE (AU-rich element) binding protein that promotes the degradation of ARE-containing transcripts [ 76], and at least six different microRNAs have been shown to negatively regulate LATS2 expression [ 77- 81].
However, the observed enrichment of transcripts with structured UTRs is not related to a particular structure, hence, it is unlikely that a particular RNA binding protein that promotes transcript stability by binding to a specific structured RNA motif is responsible for the broad expression pattern.
NFAT is a DNA-binding protein that promotes transcription of interleukin-2 (IL-2) but inhibition of IL-2 production stops proliferation and activation of T-cells to mediate the immunosuppressive effect of cyclosporine [46].
Objective: Fascin-1 is an actin-binding protein that promotes cell proliferation, adhesion and motility.
Fsp27 is a lipid droplet-binding protein that promotes lipid accumulation in adipocytes.
Candidate Akt substrates include butyrate response factor 2 (Brf2), an mRNA-binding protein that promotes mRNA deadenylation and degradation.
In 1987, they identified a 27- to 30-kDa heparin-binding protein that promotes neurite outgrowth in rat brain neurons.
