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Here, we report that RBP-J, a DNA-binding protein that integrates signals from multiple pathways including the Notch pathway, is critically involved in polarization of M2 macrophages.
65 HMGa2, a chromatin-binding protein that integrates the TGF-β response 66 is downregulated by the LET-7 miRNA family in pancreatic human cells 67 or by miR-365 in lung adenocarcinoma, 68 thus indirectly affecting SNAIL1 expression.
We also identified the landscape of PARP1-mRNA binding sites8,9, placing PARP1 in the group of chromatin binding proteins that also bind RNA.
Septin 6 (SEPT6) is a highly evolutionarily conserved GTP-binding protein that regulates various cell biological behaviors.
Satb2 is a DNA-binding protein that regulates chromatin organization and gene expression.
NF90 and splice variant NF110/ILF3/NFAR are double-stranded RNA-binding proteins that regulate gene expression.
We present here evidence that IRGM proteins affect the localization of the guanylate-binding proteins (GBPs), a second family of interferon-induced GTP-binding proteins that also function in innate immunity.
Gluten contains lectins, sugar-binding proteins that studies show can cling to insulin receptors and create insulin resistance.
Thus, phosphatases and their regulatory subunits are well equipped with domains specialized in protein/peptide binding that integrate them in the functional protein interaction network.
Maeda, K. et al. Adipocyte/macrophage fatty acid binding proteins control integrated metabolic responses in obesity and diabetes.
Here, we present the crystal structure of a T. maritima cellobiose-binding protein (tm0031) that is homologous to oligopeptide-binding proteins.
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