Sentence examples for binding protein that destabilizes from inspiring English sources
FBP1 was first found as a single-strand binding protein that destabilizes the nucleic acid duplex [ 46, 47].
In 2002, Nickenig et al. first indicated CRT as a novel mRNA binding protein that destabilizes type I angiotensin II receptor mRNA by binding to AU-rich region in 3′-UTR [ 42].
Second, Rbf1 and dE2F2 activate the expression of how (held out wings), which encodes an RNA-binding protein that destabilizes diap1 (Drosophila inhibitor of apoptosis).
These studies showed that TTP was an AU-rich element (ARE -binding protein thARE -bindingzed its target mRNA, in this case the mRNA encoding TNF-α.
Moreover, IFNβ can induce the expression of tristetraprolin, an RNA-binding protein that destabilized the mRNA of proinflammatory cytokines including TNFα [ 16].
The regulation of mRNA turnover often occurs via the 3'-untranslated region (3'-UTR) at AU-rich elements (ARE's) that are recognized and competitively bound by RNA-binding proteins that stabilize or destabilize the transcripts.
The authors speculate that TCDD affects production or activity of regulatory proteins that destabilize LH-R mRNA.
Gluten contains lectins, sugar-binding proteins that studies show can cling to insulin receptors and create insulin resistance.
Simulation of a change to helical conformation for P2 using molecular modeling indicates that such a structural transition will destabilize the F-actin-binding sites in domain 2. A hypothesis is proposed that PPIs initiate conformational changes at the PPI-binding site(s) that destabilize the protein structure, and subsequently disrupt the actin-binding sites.
For example, TS mutations often involve amino acid substitutions (mis-sense mutations) within the hydrophobic core of a folded protein that destabilize protein folding at higher temperatures [14].
ISCU protein levels are drastically reduced in patient muscle samples, perhaps because the mutation introduces a premature stop codon that destabilizes the protein.
