Sequence annotation indicated that hcgA encoded for a radical SAM-like binding protein that comprised a CX5CX2C consensus sequence, distinct from the typical CX3CX2C motif, suggesting that HcgA was a new member of the radical SAM superfamily, joining a subclass of enzymes that contain variants of the characteristic SAM binding motif (ThiC and Elp3, sections 6.2 and 10.5).
Hu-antigen R (HuR) is a ubiquitous RNA-binding protein that comprises three RNA recognition motifs (RRMs).
FUS is one of three RNA- and DNA-binding proteins that comprise the FET protein family [ 20].
Rab proteins constitute a subfamily of small GTPases that play important roles in the regulation of intracellular vesicle transport., Rab GTPases represent a large family of small guanosine triphosphate (GTP -binding proteins that comprise more than 60 known members.
More prominent proteins were cyclophilin, ubiquitin, a glycine-rich RNA-binding protein, a group of proteins that comprise a glutathione/ascorbate-based mechanism to scavenge oxygen radicals, enzymes of glycolysis and other metabolism including methionine and ethylene synthesis.
Similarly, wbmL, wbmM, and wbmN, which are within the same segment (VRB), are known to encode proteins that comprise ATP-binding cassette (ABC) transporter systems to export the O-antigen [ 10].
Nitrophorins (NPs) comprise a family of heme binding proteins that originate from the saliva of the Rhodnius species of Triatomid bugs.
In addition, CRR4, a PPR protein required for editing in Arabidopsis chloroplasts, is a sequence-specific RNA-binding protein that binds to sequences comprised of 25 nucleotides upstream and 10 nucleotides downstream of the ndhD-1 editing site (Okuda et al. 2006).
Calcineurin is a calcium/calmodulin-dependent serine/threonine-specific protein phosphatase that comprises a catalytic A (Cna1) and a regulatory B calcium-binding subunit (Cnb1).
One class of RNA-binding proteins that regulate numerous aspects of eukaryotic mRNA fate comprises the PABPs [poly(A -binding proteins].
The PUmilio-Fem-3-binding factor (PUF) proteins comprise an evolutionarily conserved family of RNA-binding proteins that are implicated in various physiological processes 10, 11.
