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Gelsolin is an actin-binding protein that circulates in the blood and plays a role in tissue damage [41].
CRHBP is the only example of a neuro-peptide-binding protein that circulates in the plasma.
There are no intracellular stores of IGF-I in the body and the very high serum concentration appears to primarily represent a circulating store, maintained by high affinity binding proteins that considerably slow clearance.
Gluten contains lectins, sugar-binding proteins that studies show can cling to insulin receptors and create insulin resistance.
There is evidence that PFOS, similarly to PFDA, displaces the thyroid hormone from its binding protein as it circulates in the blood [115].
The latter approach allowed for the identification of α1-antitripsin (a circulating protease inhibitor with anti-inflammatory functions) and S100A9 (a Ca2+-binding protein that exerts immunomodulatory effects) as possible biomarkers of clinical CDDP resistance.
Moreover, evidence also suggests that polymorphisms in the vitamin D binding protein affect circulating concentrations of 25(OH D (31).
One popular hypothesis credits insulin-like growth factor 1, a protein that circulates in the blood and is produced in greater amounts in response to exercise.
Chemokines are small, heparin-binding proteins that direct the movement of circulating leukocytes to sites of inflammation or injury [ 32].
Second, both IGF-1 and the IGF binding proteins are circulating proteins.
In addition, TTR is the dominant binding protein in rats, whereas most thyroid hormone circulates bound to TBG in humans.
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