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Besides that, zinc finger protein 174 is a DNA binding protein that acts as a cofactor for transcription factor.
Annexin B is a calcium binding protein that acts in functions such as membrane fusion, cell proliferation and differentiation, as well as cell apoptosis [ 52].
One member of the caleosin gene family, Clo3, has previously been identified as a stress inducible gene encoding a Ca2+ binding protein that acts as a negative regulator of the α subunit of the heterotrimeric G protein GA3 [ 1].
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Programmed cell death 4 (PDCD4) is a RNA-binding protein that acts as a tumor suppressor in many cancer types, including colorectal cancer (CRC).
A well-characterized substrate of LIMK1/2 is cofilin, an actin-binding protein that acts to depolymerise F-actin by its actin-severing activity.
NANOS2 is an RNA-binding protein that acts downstream of GFRA1 to promote SSC self-renewal, and is required for stem cell maintenance [ 33, 34].
These findings suggest that HOT1 contributes to the association of telomerase with telomeres and telomere length maintenance in various cellular settings, and classify HOT1 as the first direct telomere-binding protein that acts as a positive regulator of telomere length.
HMGB1 is a chromatin-binding protein that acts as a transcription factor when present in the nucleus, as well as a proinflammatory cytokine, when released extracellularly from inflammatory or dying cells.
The product of the RBM25 gene is an RNA-binding protein that acts as a splicing factor and has been shown to act on the alternative splicing of apoptotic factors 38.
The earliest step involves the recruitment of the Nup107 160 subcomplex to the chromatin surface by MEL28/ELYS (Galy et al, 2006; Rasala et al, 2006; Franz et al, 2007), a DNA-binding protein that acts as a seeding point for NPC assembly.
We have analysed the cytoarchitectural structure of such tumours by studying 3 binding proteins that act on different parts of the glandular epithelial architecture: e-cadherin, laminin, and CD44.
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