These studies suggest the effects of estrogens might be mediated through other estrogen binding proteins, rather than ERβ, even though all three ERβ agonists increased calcium oscillations.
In addition, it would be good to see a comment on the functional significance of secreting sugar binding proteins rather than having them membrane associated.
Therefore, it is possible that the insertion of Tos17 is regulated by chromatin structure or through interaction with chromatin binding proteins, rather than being controlled directly by the structures or expression levels of the targeted sequences.
Conversely, for negative T-DMRs, generalized methylation of the T-DMR may be more likely to inhibit transcription by the binding of methyl-binding proteins rather than a specific TF that only binds to methylated DNA.
It is possible, however, that LHR and HP1 co-associate by each binding to another protein rather than directly binding to each other.
We speculate that UEV-1 regulates the K63-linked ubiquitination of a small number of substrates, one or more of which is involved in GLR-1 trafficking, although we acknowledge that we cannot rule out the alternative possibility that UEV-1 and UBC-13 regulate GLR-1 trafficking by binding ubiquitinated proteins rather than catalytically modifying their K63 linkages.
Studies show that consideration of residues in the 'binding neighborhood' of a protein rather than just the binding residues, improves prediction [ 29].
First, the assay used a transcription protein rather than a simple DNA binding protein as a quantitative test of the Sir protein transcriptional repression mechanism.
These findings further suggest that BxACE-3 function as a ubiquitous sequestration protein, rather than as a specific hydrolase, by binding nonspecifically to a variety of xenobiotics.
With respect to TGFβ-1, binding to decorin has been shown to be with the core protein rather than with the DS chain.
