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One such PS binding protein is the C2 domain of synaptotagmin I, which binds to anionic phospholipids in cell membranes [ 47].
A prominent example of an RNA G-quadruplex binding protein is the fragile X mental retardation protein FMRP39, but it is currently unknown whether FMRP is sequestered by the C9orf72 expanded GGGGCC-repeats.
This DNA binding protein is the transcriptional factor of an evolutionarily conserved regulatory pathway that drives expression of a large number of genes involved in proinflammatory processes at the site of infection or tissue damage.
This cold induced RNA binding protein is the only gene consistently over expressed across different tissues in hibernating ground squirrels [ 4- 6] and black bears [ 11].
A more conserved CPEB associated eIF4E binding protein is the neuronal protein neuroguidin, which has been proposed to function in a similar manner to maskin in repressing translation in the nervous system [139].
Another key telomere binding protein is the yeast Ku complex (referred to as YKu), composed of Yku70p and Yku80p (Boulton and Jackson 1996; Porter et al. 1996; Gravel et al. 1998).
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Some disease-related genes, such as several LRR family disease-resistance proteins and a GTP/RNA binding protein were the unique target of BSL6 siRNAs.
A valuable addition to the present repertoire of binding proteins is the recently developed designed ankyrin repeat protein (DARPin) technology.
The superfamily of nucleic acid binding proteins is the most populated.
Whilst the region of the chemokine that interacts with the chemokine-binding protein is the same, many of the specific amino acids involved in the interactions are not.
Finally, vitamin D-binding protein is the main carrier for vitamin D and its metabolites, known to be essential in the development, function, and maintenance of healthy bones through the regulation of calcium homeostasis (Speeckaert et al. 2006).
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