Cyclophilin C-associated protein (CyCAP) or Mac-2 binding protein has been identified as a binding protein for cyclophilin C in mice and for Mac-2 (galectin-3) in human, suggesting its multiple binding activity to proteins.
More recently HP68, a cellular ATP binding protein, has been shown to be important for capsid formation and an interaction between Vif and HP68 has been shown.
At least one cellular mRNA, encoding a heat shock-like protein, glucose-regulated protein 78/immunoglobulin heavy-chain binding protein, has been discovered to be translated at an increased rate in poliovirus-infected cells at a time when the translation of other cellular mRNAs is inhibited.
However, purified garlic leaf lectin (ASAL), a 12 kDa dimeric mannose binding protein has been found to have detrimental effect on growth and survival of two important homopteran insect pests, Lypaphis erysimi, commonly known as aphids and Dysdercus cingulatus (red cotton bug).
Intriguingly, however, a SNP linked to a gene that interacts with ATXN2, Ataxin-2 binding protein, has been identified as significant [50], [54].
Induction of glucose-regulated protein GRP78, also referred to as BiP (immunoglobulin heavy-chain binding protein), has been widely used as a marker for ER stress and the onset of UPR.
Although the first guanylate binding protein had been described almost 30 years ago further family members have been discovered lately.
Recent progress towards artificial DNA binding proteins has been achieved by structure-based design processes and by selection strategies.
New methodology for detecting sequence-specific DNA binding proteins has been recently developed (T. Heyduk, and E. Heyduk, Nat. Biotechnol. 20 (2002) 171).
