Taken together, the binding kinetics of durvalumab is much similar to that of atezolizumab, while binding properties of BMS-936559 and avelumab are distinct from the above two MAbs.
However, the lipid binding properties of aS are strongly impacted by acetylation and exhibit distinct behavior for the first 12 residues, indicative of an initiation role for the N-terminal residues in an "initiation elongation" process of binding to the membrane.
As expected, differences in the binding properties of AChE from liver, brain and RBCs to lectins indicate a distinct pattern of glycosylation derived from different cellular origins of the AChE protein.
In addition, we performed ZEB1 ChIP-seq at distinct time points during adipogenesis, providing a first glance into the dynamic DNA binding properties of ZEB1 in any biological system.
Saturation binding studies were carried out to analyse the in vitro binding properties of the diabody.
This structure still retains the binding properties of classical antibody.
The binding properties of a motif or a motif-binding domain can also be modulated indirectly by allosteric effects, resulting from modification or effector association/dissociation at a site that is distinct from the actual interaction interface [ 99– 101] (Fig. 2g).
3) Could the DNA-binding or protein-binding properties of c-myc contribute to their distinct diffusing populations (or the relative proportions of each population)?
This difference is likely explained by distinct ligand-binding properties of mER-α due to structural differences (posttranslational modifications; Li et al. 2003) or a dramatic impact of the microenvironment (membrane border lipid contact).
The structure of RolR-resorcinol complex in comparison with the apo-form of RolR revealed unique recognition and binding properties that are distinct from the previously observed TetR proteins [3].
The metal-binding properties of MT-1/2 have been well investigated, and it is recognised that these proteins are capable of binding 7 divalent (Zn2+) and up to 12 monovalent (Cu+) metal ions in vivo through two distinct metal-thiolate clusters, termed the α- and β- domains [16].
