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It can be argued that L5 and L23, which also have MDM2 binding properties, may be responsible for the observed increased p53 activity in L11-deficient embryos.
The data suggest that tumour cells synthesise HS, but its binding properties may be modified by SULF action.
A comparison of the structure-induction (involving rat and mouse Ah receptor binding) and structure-toxicity (in vivo guinea pig toxicity) relationships suggests that two receptors with structurally distinct binding properties may be involved.
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It is reasonable to believe that this low binding property may be extrapolated to human serum albumin [ 41].
As in the case of the Duffy antigen binding chemokines, this erythrocytic property may be important in absorbing excess stimulant signals intended for inflammatory cells, thereby modulating immune responses [ 21].
This property may be particularly important in the case of 2'-deoxy NTPs, which are not discriminated during initial binding and, therefore, compete with the cognate rNTPs.
New catalytic activities and metal binding properties may have evolved, as is the case of the tyrosinase-related protein 2, which uses zinc instead of copper as cofactor.
Although few G225R mutations were found, they were all found in avian hosts, indicating that the mutation can occur sporadically and avian-like receptor-binding properties may not be fully abolished by G225R.
The telomere-binding properties may also be a subject of rapid adaptive coevolution of function as occurs with another essential structure, centromeric repeats and specific centromeric histone types (Malik and Henikoff 2001).
Thus, compared to conventional liposomes, liposomes made from fluoroalkylated PCs have different binding properties, which may be relevant to their use as drug carriers.
In vivo, it is possible that "good" binding properties promotes proliferation and/or survival, but that also NK cells with less good self-MHC binding properties may pass selection and survive, although to a lesser extent.
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