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MAPPIS performs multiple alignments of the physico-chemical interactions and the binding properties in three dimensional space.
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In this study, we focused on the F-THK5117 thater that was reported to have good binding properties in AD tissue [ 17].
Studies with [3H]prucalopride demonstrated favourable radioligand binding properties in vitro [5].
In this study, we characterized the in vitro binding properties of THK5117 in large frozen sections from autopsied AD brains, and compared its binding pattern with measured tau histopathology as well as with previous in vivo measurement of F-FDG and C-Pittsburgh compound B (PIB) PET imaging in the same patients.
The first aim of this study was to examine the binding properties of AZD2995 in a preclinical setting and compare these properties with those of AZD2184 and PIB.
In this study we characterized the in vitro binding properties of THK5117, a tentative radiotracer for positron emission tomography (PET) imaging of tau brain deposits.
Both mutations, the stark increase in the side chain size of the Gly1018Arg mutation and the helix binding properties of the Leu1079Pro mutation, could potentially change the geometry of the selectivity filter and block ionic flux.
It has properties in 11 states.
Interestingly, sialylation of OPN has been shown to influence its binding properties (Shanmugam et al, 1997).
It is not known whether compounds like these interfere with the AnxA2-binding properties of S100A4.
In parallel, we investigated the DNA-binding properties of hTERT 1 300 variants containing the Q169 substitutions.
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