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The 'Z-site' glycine residue, which is a site for binding cholesterol analogues in human CES1, has been substituted in the opossum CES1 sequence (355Ala) which may reflect a change in the ligand binding properties for this enzyme.
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Molecularly imprinted polymers (MIPs) displaying selective binding properties for the mycotoxin ochratoxin A (OTA) in polar/protic media were prepared.
Antibodies are the most widely used ligand, but can be expensive to produce with limited control of the production time or the binding properties for the target protein.
Altered binding properties for the DSG2 A517V change were not identified.
The association of hypoglycaemia, on the other hand, was most pronounced for antidepressants with corresponding binding properties for the serotonin reuptake transporter.
The association of hyperglycaemia was most pronounced for antidepressants with corresponding binding properties for the 5-HT2c receptor, H1 receptor and NE reuptake transporter.
The association was most pronounced for antidepressants from cluster 2 and cluster 3 with corresponding binding properties for the 5-HT2c receptor, H1 receptor, respectively, norepinephrinic (NE) reuptake transporter.
The isolation of geometrical isomers is less well established and so binding properties for these compounds have not been explored although simple anion recognition has been studied.
Both IL-13 variant proteins, E11A and R64A, were prepared and their binding properties for the ECDs of IL-13Rα1 and IL-4Rα were determined by BIAcore analysis.
We found that the association between hypoglycaemia and the use of antidepressants was most pronounced for antidepressants from cluster 1 and cluster 2 with corresponding binding properties for the serotonin reuptake inhibitor.
We found that the association between hyperglycaemia and use of antidepressants was most pronounced for antidepressants from cluster 2 and cluster 3 with corresponding binding properties for the NE reuptake transporter, 5-HT2c receptor and H1 receptor.
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Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com