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This work describes the design and expression of a stereoselective Fab that possesses binding properties comparable to those displayed by the parent monoclonal antibody.
Our most advanced candidate exhibits structural and bnAb binding properties comparable to full-length HA, completely protects mice in lethal heterologous and heterosubtypic challenge models, and reduces fever following sublethal challenge in cynomolgus monkeys.
10Fn3-based target-binding proteins have binding properties comparable to those of antibodies, but they are smaller, simpler in architecture, and more user-friendly; as a consequence, these proteins are excellent building blocks for the construction of multidomain, multifunctional chains.
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Among the twelve proposed extensions in different combinations, compound 14 (consists of para-fluoro phenyl group as both P1 and P1′ moieties) was identified as a lead with improved binding profile, binding affinity against the MDR protease and favorable predicted pharmacological properties comparable to those of LPV.
The R599A/Q602A mutation – located in the vicinity of RapA's putative ATP-binding cleft (Figure 6B, bottom panels) – yields non-functional mutant RapA with folding and solubility properties comparable to those of wild-type RapA [24].
PRONE was found to stimulate nucleotide dissociation from ROP with catalytic properties comparable to DH PH GEFs.
CXCL12-GL has bioluminescence properties comparable to unfused GL and CXCR4-dependent signaling to a comparable extent as unfused secreted or synthetic CXCL12.
We recently established a v-myc immortalized human NSC (IhNSC) line, which retains stem properties comparable to parental cells.
S1P has signaling properties comparable to those of LPA while acting on S1P receptors.
The researchers demonstrated that Drosophila Spz, Spz2 and Spz5 have neurotrophic properties comparable to neurotrophins.
The second factor is an ideal scaffold, which possesses mechanical properties comparable to bone.
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