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A shortened IR, consisting of residues 1 601 and 650 719, displays the same insulin binding properties as the holoreceptor, suggesting that all residues needed for high affinity binding are located within these regions [80].
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The reported experimental characterization of ligand binding properties as well as the small size and the multi-domain organization and structural simplicity of PDC109 qualify it as an ideal model system to explore the use of explicit solvent MD simulations to study ligand binding and conformational dynamics in multi-domain proteins.
This provides the structural basis for understanding the substrate binding properties as well as conformational change upon substrate binding (Mulligan et al., 2014).
She reported novel insights into the function of Foxp3 related to its binding properties as well as suppressive abilities.
This review describes the advantages arising from the use of CRP in synthesizing MIPs, both in terms of sheer binding properties as well as for their remarkable potential for post-polymerization functionalization, for the synthesis of MIP nanomaterials and for the integration of MIPs into composites and hybrid materials.
Secondly, mutagenesis, competitive dissociation analysis and differential scanning calorimetry were used to compare and study the biotin-binding properties as well as the thermal stability of AVRs and avidin.
Aside from the evolutionary and functional implications of the conservation of LSECtin function, the close similarities in their ligand-binding properties, as well as the similar restricted distribution of tissues in which they are expressed, provide a firm foundation for use of mouse LSECtin as a model for the human receptor, which is not always possible in the case of more divergent receptors.
We designed and produced multirepeat proteins comprising three to five repeats and report their lipid-binding properties as well as their thermal stabilities.
Members of other families include various proteins with metal-binding properties as well as proteins with a role in vesicle and transmembrane transport (supplementary table S11, Supplementary Material online).
Therefore, it has been unclear whether these domains share the same RNA-binding properties as the RGG box of FMRP.
However, overnight incubation of ECo-nNOS with BH4 yielded an enzyme with very similar pterin-binding properties as the Sf9-expressed enzyme.
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Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com