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We have computed the normalized binding propensity of all the 20 amino acid residues in different organisms (E. coli, H. sapiens, S. cerevisiae, thermophiles and archaea) and the results are shown in Figure 1.
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On the other hand, Ser, Tyr, Gln, Asn, Lys, Arg and His have the binding propensity of more than 2 in all the organisms showing their preferences at the interface.
The maximum discriminant function score across all windows in a protein can be used as the CaM binding propensity of that protein.
Tagging a cysteine residue at the terminals not only enhances the binding propensity of the resultant peptide with the silver nanoparticle, but also increases its antimicrobial property against several pathogenic bacterial strains including K. pneumoniae.
Interestingly, we noticed few differences in the binding propensity of residues among different organisms.
We have evaluated the influence of RNA base sequence on the binding propensity of amino acid residues in nucleotides.
Authors' response: We have evaluated the influence of RNA base sequence on binding propensity of amino acid residues in nucleotides.
The catRAPID algorithm exploits predictions of secondary structure, hydrogen bonding and van der Waals' contributions to estimate the binding propensity of protein and RNA molecules.
These results are similar to the binding propensity of residues obtained with energy based approach in a set of 81protein-RNAprotein-RNA [ 4].
To infer the determinants of the ligand binding propensities of WW domains, we analyzed 42 WW domains.
The binding propensities of polar residues showed high variability among different organisms at conserved positions.
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