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Indirect Binding Assay: The aluminum binding propensity of each sorting round, a population consisting of a single isolate or the empty display vector (negative control) were compared by quantifying the number of cells recovered from the aluminum surface.
The higher Kb value of l-tryptophan complex 1 suggested greater DNA binding propensity.
Hence, vascular drug particle design needs to be tailored to account for higher binding propensity at larger bifurcation angles.
On the basis of binding propensity at the different pockets and inhibitor constants, we ranked these isomers as potential candidates for the HCV inhibition.
A flexible sidechain model with flexible dihedral angles for up to 12 aminoacids increased both binding propensity and enrichment rates: EF_1 values increased by 35% on average with respect to rigid-docking (3-8 flexible sidechains).
The results of corroborative experiments reveal that the complexes avidly bind to CT DNA via groove binding, with highest Kb values for 1 indicative of strong binding propensity as compared to ligands and 2 4.
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First, considerable variations in fibril binding propensities are observed along the Aβ sequence.
To infer the determinants of the ligand binding propensities of WW domains, we analyzed 42 WW domains.
The former appears to be the main site of fatty acid binding, and the latter may have different, though possibly overlapping, ligand binding propensities.
One study that focused solely on ranking of pockets previously found by other pocket detection algorithms introduced an approach based on amino acid composition and relative ligand binding propensities of different amino acids termed PLB index [29] (we compare our proposed method with PLB index in results section).
The correspondence between the computed scores and binding propensities points to a subtle interplay between DNA sequence and nucleosomal folding, e.g., sequences with periodically spaced pyrimidine-purine steps deform at low cost along a kinked template whereas sequences that resist deformation prefer a smoother spatial pathway.
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