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First, considerable variations in fibril binding propensities are observed along the Aβ sequence.
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In particular, the difference in ignition propensities was observed at temperatures at which the low temperature branching reactions are active.
Of note, clonal - rather than inter-patient - variations in differentiation propensities were observed within the tested cohort.
Unexpected binding patterns are observed for oligonucleotides.
However, for a growing number of TFs, models of their DNA-binding propensities are known.
(ii) The binding propensity was normalized with the percentage of binding site residues in the considered protein-RNA complexes.
Linear correlations between the predicted binding scores and the experimentally measured binding affinities were observed.
The same binding pattern was observed for U36 as expected.
No binding to BiP substrate binding domain was observed.
KLF4 and Sp5 binding was observed at both esBAF and GBAF binding sites, with slightly greater occupancy at GBAF complex binding sites.
Whereas no binding was observed with the scrambled sequences, an increase in size was detected with oligonucleotides with increasing number of binding sites (Fig. 3b, right panel).
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