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The accumulating AGEs spread out of the cell, inducing non-receptor-dependent changes in the extracellular matrix molecules [ 30] and modifying circulating proteins, which then bind to AGE cell receptors; this binding prompts the production of inflammatory cytokines, which in turn cause vascular injury [ 31].
Taken together, the above results suggested that Plk1 interacts via its PBD with a phosphorylated form of hBora and that this binding prompts hBora phosphorylation by Plk1.
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While that language does not impose any limit on the American program, Russian officials have called it "binding," prompting criticism in the United States.
MUC imparts viscoelasticity to mucus and participates in foreign particle adhesion and pathogen binding, prompting their clearance via ciliary beating or coughing.
The initial observation that adaptor β-barrel topology is also found in domains involved in ligand binding prompted the idea adaptors may have a role in substrate engagement [40].
The displaced target forms another specific probe-target binding and prompts cycled polymerization reactions.
The impact of fragment-based drug discovery (FBDD) on recent drug discovery projects and our improved knowledge of the structural and thermodynamic details of ligand binding has prompted us to explore the relationships between ligand-binding thermodynamics and FBDD.
The potential of simultaneously targeting both modules with pterin binding inhibitors prompted us to characterize the molecular details of the multifunctional complex.
The similarity between the NTD and LBD binding pattern prompted us to probe the specificity of this interaction further.
Shim et al. [19] reported that EGCG binds to ZAP-70 kinase at the catalytic site and blocks the ATP-binding pocket, prompting us to examine whether EGCG could have a similar effect on RIG-I.
The non-binding vote prompted Eurosceptics to call on the government to consider withdrawing from the court.
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