Sentence examples for binding promiscuity and binding from inspiring English sources
Among the list of structural features that make IDPs especially useful for their signaling and regulation functions include induced folding, binding promiscuity, and binding plasticity.
They explored the similarity between drugs and native ligands as an indication for possible binding promiscuity and the use of this information to suggest alternative drug targets.
The intrinsic structural disorder of the PD key protein AS accounts for ligand binding promiscuity and conformational variance.
Of all the REF-1 family proteins, HLH-25 has the greatest degree of DNA-binding promiscuity and tightly binds to five E-box-like sequences.
These findings support the importance of structural constraints in preventing aggregation [70], [73] and structural flexibility in binding promiscuity [72], and also provide new clues to regulate protein-protein interactions through controlling the flexibility of proteins or binding motifs.
The most abundant and crossreactive of these antibodies (CK3) recognized the biotinylation sequence located at the C-terminus of each chemokine, thus explaining its exquisite promiscuity and similar binding affinities for the various chemokines.
This review aims at discussing the molecular details of binding specificity, promiscuity and mechanisms of phosphopeptide recognition to modular domains using computational tools.
The changing frequency of HLA alleles in the general population results in a third challenging observation: binding promiscuity between HLA variants and drugs.
In order to remain multi-functional and exhibit their characteristic binding promiscuity, they need to retain considerable dynamic flexibility.
An example is cancer drugs such as Gleevec (imatinib) and Sutent (sunitinib) that show binding promiscuity for multiple kinases [4].
In addition to binding promiscuity, unstructured regions could allow for variable post-translational modifications and rapid degradation when not in complex with their binding partners.
