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Typically, we would calculate the RAS for a large number of TFs (e.g. in matrix |S|, we have 424 TF binding profiles generated by the ENCODE project).
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To further investigate this possibility, we analyzed chromatin classes based on protein-binding profiles generated by Filion et al. (2010), who defined five chromatin states: GREEN (pericentric heterochromatin), BLUE (Polycomb heterochromatin), BLACK (intercalary heterochromatin), RED (active chromatin), and YELLOW (active chromatin).
The general conclusions from these studies were that binding profiles generated from ChIP-chip and ChIP-seq were largely correlated at the genome-wide level, and that ChIP-seq had superior sensitivity and specificity over ChIP-chip in terms of binding site identification as determined by motif enrichment or quantitative PCR validation.
DOI: http://dx.doi.org/10.7554/eLife.04837.022 10.7554/eLiFigure3 figureigure 3—figure supplement 1. Similarity of binding profiles generated using HT-SELEX and B1H.
A comparison of the concentration profiles generated by Model 1 and Model 2 clearly reveals the impact of cooperativity on Ca2+ binding to CaM.
This paper proposes an efficient approach for generating velocity profiles that cannot be generated by previous techniques as well as velocity profiles generated by them.
Urine protein profiles generated by SELDI-TOF-MS analysis showed different spectra among groups.
We present here unique cytological profiles generated by HCA from three historical patients affected by CAIS or PAIS, which were complemented by NH2-COOH-terminal domain interaction (NC-TDI) experiments, and previously published ligand-binding studies [11].
The velocity profiles generated by these equations are plotted as a function of r (Figure 4).
Interpretation of DNA profiles generated by PFGE was done visually.
A comparison of gene profiles generated by hypoxia was performed against the profile generated by cells treated with hypoxia plus NO [Additional file 4].
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Justyna Jupowicz-Kozak
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