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The ligands 7 and 11 have displayed the highest binding profiles for the μ-opioid receptor binding site with ΔGbind (−12.14 kcal/mol) and Ki value (1.0 nM), and ΔGbind (−12.41 kcal/mol) and Ki value (0.4 nM), respectively.
The comparison of AChE-lectin binding profiles for the two mannose specific lectins, LCA and Con A, give no definitive conclusion because the enzyme in plasma does not reproduce the binding pattern of a single tissue, probably due to the diverse number of cellular origins.
The corresponding z-ratios [Equation (23)] indicate strong correlations between binding profiles for the PcG proteins and for H3me3K27 marks (Fig. 2b).
The PCC was calculated using binding profiles for the wild-type and mutant strains, showing the effects of gene deletions on the Htz1-bound genes for the 40 gene clusters.
We compared PS, PtdIns, PtdInsPs, PtdInsP2s, and PtdInsP3 binding profiles for the Syt1-C2AB fragment with the lipid biding profiles of the Syt1-C2AB Lys326Glu/Lys327Arg398Glu/Arg399Glurg399Glu mutants.
In fact, the ΔASA-based binding profiles for the single IDR of p53 bound to four different partners were completely different, indicating that the same residues were used to different extents in the four interfaces, suggesting that the same IDR sequence is "read" by the different partners in entirely different ways [ 51].
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The binding profiles for these target gene loci showed that most have a strong enrichment for Esg-Dam binding at the 5′ UTR of their transcript isoforms, that is, close to the transcription start site (Fig 4C).
A similar observation is made for data sets obtained with the other two antibodies against the unmodified CTD and the Ser5-P; however, the switch between early and late binding profiles for these two forms occurs earlier between T3 (24 hpi) and T4 (32 hpi).
Thus, we compared binding profiles for these proteins over 10 kb regions centered around insertion sites of reference transgenes which were mapped to the interbands studied and used to clone respective DNA sequences (Additional file 1 Figure S1, Additional file 2 Table S1).
Further, we used z-scores of the total binding affinity (TBA), which uses a TF binding profile for the whole promoter based on position weight matrices (Molineris et al., 2011).
As the most extreme example of this apparent incongruence, the most prominent peak found in the in vitro binding profile for the closed and open complexes coincides with the λPBL promoter.
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