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The anti-apoptotic members of Bcl-2 family of proteins bind to their pro-apoptotic counterparts to induce or prevent cell death.Based on the distinct binding profiles for specific pro-apoptotic BH3 peptides, the anti-apoptotic Bcl-2 proteins can be divided into at least two subclasses.
To investigate the function of Drosha at the beginning of human genes in more detail, we compared Pol II and Drosha binding profiles for specific human genes.
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In the JASPAR database, we only considered the binding profiles for plant-specific TFs because of their potential critical roles in regulating the accumulation of storage reserves during seed development, a unique physiological process in higher plants.
The comparison of AChE-lectin binding profiles for the two mannose specific lectins, LCA and Con A, give no definitive conclusion because the enzyme in plasma does not reproduce the binding pattern of a single tissue, probably due to the diverse number of cellular origins.
(b) ChIP-seq binding profiles for Med1, Smad3 and PU.1 at the locus of Foxo1 gene.
Julia Zeitlinger, Alexander Stark and colleagues report genome-wide binding profiles for the transcription factor Twist across six Drosophila species.
Zoomed binding profiles for both TFs are highly similar, which is a striking observation given that both profiles were recorded in different growth conditions (sucrose-supplemented for LysM-specific ChIP versus tryptone-supplemented medium for Ss-LrpB-specific ChIP).
Thus, defining the in vivo binding profile for additional cell-specific regulators of cardiogenesis should vastly improve cell type-specific predictions, as we observed.
Strikingly, the p73 binding profile is indistinguishable from the previously described binding profile for p63 in the same cells.
Briefly, the 118 TF binding profiles (position-specific weight matrix, or PWM) were compiled from the literature [ 27, 74] and the JASPAR database [ 78], and converted into a format suitable for each software tool (Additional File 4).
Make config files so that you can load specific profiles for specific game-types.
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Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com