Sentence examples for binding profile in the from inspiring English sources
We used the suite of successful input spacer sequences to build a binding profile, in the same manner that sequences from a SELEX scan of a transcription factor are used to determine the consensus binding site [ 23].
One possibility is that dysregulation of histone deacetylation activities after TSA treatment significantly alters the Sox2 binding profile in the genome to a more random state; the other possibility is that TSA treatment redistributes the 3D localization of existing Sox2 binding sites in the nucleus.
After checking the average H3K4me2 binding profile in the extended TSS region for those genes shared with 356-gene list, only the cluster 6 of ES (97 common genes) shows H3K4me2 labeling downstream of TSS (panel B in Figure 4), while both the NP cluster 2 (140 common genes) and 6 (82 common genes) show significant H3K4me2 labeling downstream of TSS (panel D and F in Figure 4).
We then used anti-glycan lectin probes to obtain binding profiles in the same cell lines and compared the two types of profiles.
This analysis enabled to identify 170 genes in the vicinity of accelerated regions that display significantly altered transcription factor binding profiles in the human genome compared to chimpanzee.
We systematically analyzed a large collection of ChIP-Seq TF binding profiles in the A549 lung adenocarcinoma cell line.
Thus, we sought to investigate whether the relatively high incidence of these compounds with flat binding profiles in the MIT-2 library was due to their being designed to bind within the substrate envelope or was instead a result of their being based on an advantageous scaffold.
As a proof-of-principle, we assessed AR chromatin binding profiles in this study.
The fluorinated WT1J-W4WF showed the best binding profile in both a time- and a dose-dependent manner compared with WT1J and the rest of the J analogs.
This modification did not substantially affect the receptor binding profile in comparison to its 3-chloro counterpart (2 vs 3), except for an increase in the affinity for D2Rs.
As some CTCF binding events overlap with ER and FOXA1 binding events, we assessed whether the CTCF binding profile in an ER-negative cell line, lacking ER and FOXA1 expression, would differ.
