Sentence examples for binding profile in both from inspiring English sources
The fluorinated WT1J-W4WF showed the best binding profile in both a time- and a dose-dependent manner compared with WT1J and the rest of the J analogs.
The disulfide- and Michael acceptor-functionalized compounds showed significant receptor affinity and an irreversible binding profile in radioligand depletion experiments.
This modification did not substantially affect the receptor binding profile in comparison to its 3-chloro counterpart (2 vs 3), except for an increase in the affinity for D2Rs.
Interestingly, ER shows a distinct binding profile in patients with poor clinical outcome to anti-estrogen therapies.
Such a modified ER binding profile in poor prognosis tumours was associated with upregulated expression of corresponding genes.
As some CTCF binding events overlap with ER and FOXA1 binding events, we assessed whether the CTCF binding profile in an ER-negative cell line, lacking ER and FOXA1 expression, would differ.
We used the suite of successful input spacer sequences to build a binding profile, in the same manner that sequences from a SELEX scan of a transcription factor are used to determine the consensus binding site [ 23].
To achieve this, we modified the REACTIN algorithm to calculate a regulatory score of a TF for each samples in a microarray dataset (see "Methods" for details), resulting in an activity profile for each TF binding profile in our ChIP-seq data collection.
One possibility is that dysregulation of histone deacetylation activities after TSA treatment significantly alters the Sox2 binding profile in the genome to a more random state; the other possibility is that TSA treatment redistributes the 3D localization of existing Sox2 binding sites in the nucleus.
After checking the average H3K4me2 binding profile in the extended TSS region for those genes shared with 356-gene list, only the cluster 6 of ES (97 common genes) shows H3K4me2 labeling downstream of TSS (panel B in Figure 4), while both the NP cluster 2 (140 common genes) and 6 (82 common genes) show significant H3K4me2 labeling downstream of TSS (panel D and F in Figure 4).
