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In the category of RNA binding, processing, and transcription, 128 genes encoding transcription factors (TFs) were identified.
The competence state is highly regulated and reflects a window in which the proteins required for DNA binding, processing, and internalization are produced.
The genes involved in RNA binding, processing, and transcription, protein targeting and degradation, signal transduction, miscellaneous enzyme families, and transport were well represented.
On the enzymatic level, the saccharolytic machinery in B. thetaiotaomicron includes a large number of extracellular and periplasmic proteins involved in polysaccharide binding, processing, and cleavage.
These proteins have been implicated in poly(A)+ mRNA binding, processing and export [ 17], ribosome biogenesis [ 18- 20] and gene silencing [ 21].
Despite the overlap of only 449 genes, comparison of functional enrichment analyses identified DEGs associated with lipid binding, processing, and metabolism, oxidative stress, immune responses, cell adhesion and movement, and extracellular matrix remodeling within RNA-Seq and Agilent data sets (Additional file 3: Table S2) consistent with previous reports [ 32, 34].
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This study clearly shows the dynamic structures within the RNA-binding domains, which provides additional insights on mechanism of asymmetric RNA binding and processing.
This so far unobserved subsite distortion is incompatible with productive substrate binding and processing.
All-trans- and 11-cis-retinol derivatives substituted with various electron-withdrawing groups at C12 were designed to be affinity labels for retinol binding and processing proteins.
Indeed, nucleic acid binding and processing enzyme genes represented the largest functional category with several helicases among them.
These combined effects would thus counteract competitive displacement of the inhibitor by physiological substrates, which require previous exosite I binding for processing.
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